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. 2021 Oct 20;9:740455. doi: 10.3389/fcell.2021.740455

FIGURE 5.

FIGURE 5

Competing endogenous RNA (ceRNA) network construction and immune, cancer stemness, and drug sensitivity analysis. (A) The genome instability-related ceRNA network in colon adenocarcinoma (COAD) based on ENCORI. (B–H) The differential expression analysis included three lncRNAs (BOLA3-AS1, AC124067.4, AL161772.1) and four target mRNAs (NINL, SALL4, TNFSF11, PHYHIPL) by Mann-Whitney U test. (I) The correlation between the expression of each lncRNA and its target mRNAs based on ENCORI. (J) The association between the seven gene expression and five immune subtypes in COAD. (K) The association between the seven-gene expression and cancer stemness based on mRNA expression (ssRNA) and DNA methylation patterns (DNAss); the association between the seven-gene expression and the ESTIMATE immune score, stromal score, and ESTIMATE score. (L) The association between the seven-gene expression between drug sensitivity based on the NCI60 database (top 16 ranked by correlation). *p < 0.05, ** p < 0.01, and ***p < 0.001.