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. 2021 Oct 20;9:740455. doi: 10.3389/fcell.2021.740455

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Copyright © 2021 Ren, Wang, Gu, Ma, Zhu, Cai and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Somatic mutation and copy number variation (CNV) analysis of three lncRNAs (BOLA3-AS1, AC124067.4, AL161772.1) and four target mRNAs (NINL, SALL4, TNFSF11, PHYHIPL). The alteration rates and types of NINL (A), PHYHIPL (B), SALL4 (C), and TNFSF11 (D). The alteration sits of each gene on the coding protein domains for NINL (E), PHYHIPL (F), SALL4 (G), and TNFSF11 (H). The comparison of gene expression between wild type and mutated type for NINL (I), PHYHIPL (J), SALL4 (K), and TNFSF11 (L). (M) The location on a chromosome and the most common CNV status of the four target mRNAs. (N) The association between gene expression and CNV for NINL, PHYHIPL, SALL4, and TNFSF11.