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. 2021 Oct 20;9:740455. doi: 10.3389/fcell.2021.740455

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Copyright © 2021 Ren, Wang, Gu, Ma, Zhu, Cai and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The association between the three lncRNAs (BOLA3-AS1, AC124067.4, and AL161772.1), four target mRNAs (NINL, SALL4, TNFSF11, and PHYHIPL), and the tumor mutational burden (TMB), microsatellite instability (MSI) score, and MSI status. (A) The association between the three lncRNA expression and the TMB in pan-cancer using Spearman’s correlation. (B) The association between the three lncRNA expression and the MSI score in pan-cancer. The association between the four target mRNAs and the TMB (C) and MSI score (D) in pan-cancer. (E) The comparison of the MSI status between the wild type and mutated type of the four target mRNAs (adjusted by each gene mutation rate) in COAD based on cBioPortal. (F) The association between the MSI status and the copy number variation of the four target mRNAs in COAD based on cBioPortal.