Table 2.
Treatment sequences# in the included studies.
| References | Consideration of the treatment sequence | First-line treatment | Second-line treatment | Third-line treatment |
|---|---|---|---|---|
| Einarson et al. (15) | Yes | Paliperidone LAI or olanzapine LAI or risperidone LAI or oral olanzapine or haloperidol LAI | Olanzapine LAI or paliperidone LAI or haloperidol LAI or oral olanzapine* | Clozapine |
| Lachaine et al. (16) | Yes | Asenapine or olanzapine | Aripiprazole or ziprazidone or risperidone or quetiapine | NA |
| Park et al. (17) | Yes | Olanzapine or risperidone or quetiapine or ziprasidone | Olanzapine or risperidone or quetiapine or ziprazidone* | Clozapine |
| Dilla et al. (18) | Yes | Olanzapine LAI or risperidone LAI | Other antipsychotics | NA |
| Anh et al. (19) | No | Chlorpromazine or haloperidol or levopromazine or risperidone or clozapine or olanzapine | NA | NA |
| Lubinga et al. (20) | Yes | Chlorpromazine or haloperidol or risperidone or olanzapine or quetiapine | Risperidone or haloperidol* | Perphenazine |
| Druais et al. (21) | Yes | Paliperidone LAI or risperidone LAI or aripiprazole LAI or olanzapine LAI or haloperidol LAI or oral olanzapine | 25%paliperidoneLAI+25%risperidone LAI+25%aripiprazoleLAI+25%olanzapine LAI** | NA |
| Lin et al. (22) | Yes | Amisulpride or aripiprazole or chlorpromazine or haloperidol or olanzapine or paliperidone or quetiapine or risperidone or sulpiride or trifluoperazineor ziprazidone | The other drugs excluded the first-line drugs*** | Clozapine |
| Rajagopalan et al. (23) | Yes | Lurasidone or aripiprazole | Amisulpride | Clozapine |
| Einarson et al. (24) | Yes | Aripiprazole or paliperidone or olanzapine or risperidone | Olanzapine or risperidone* | Clozapine |
| Einarson et al. (25) | Yes | Paliperidone or risperidone or haloperidol or olanzapine | Haloperidol or olanzapine* | Clozapine |
| Barnes et al. (26) | No | Olanzapine or amisulpride | NA | NA |
| Einarson et al. (27) | Yes | PP3M or PP1M | Aripiprazole | Clozapine |
| Einarson et al. (28) | Yes | PP3M or PP1M or haloperidol or risperidone or olanzapine | Haloperidol or oral olanzapine | Clozapine |
| Wiwat et al. (29) | Yes | Aripiprazole or risperidone | Clozapine | NA |
| Nuhoho et al. (30) | Yes | Paliperidone LAI or paliperidone LAI plus oral antipsychotics | Risperidone or paliperidone or aripiprazole or olanzapine or quetiapine*** | Risperidone or paliperidone or aripiprazole or olanzapine or quetiapine* |
| Aigbogun et al. (31) | Yes | Brexpiprazole or cariprazine or lurasidone | Olanzapine or risperidone or quetiapine or ziprazidone or aripiprazole** | NA |
| Németh et al. (32) | No | Cariprazine or risperidone | NA | NA |
| Zhao et al. (33) | Yes | Olanzapine ODT or olanzapine SOT or aripiprazole SOT | Aripiprazole or amisulpride or ziprazidone or clozapine | NA |
| Abdall-Razak et al. (34) | No | Paliperidone or amisulpride | NANA | |
| Dutina et al. (35) | Yes | Aripiprazole or olanzapine | Clozapine | NA |
| Arteaga et al. (36) | Yes | PP3M or PP1M | Paliperidone, olanzapine, aripiprazole, risperidone*** | NA |
| Yi et al. (37) | No | Amisulpride or olanzapine | NA | NA |
| Lin et al. (38) | Yes | Aripiprazole ODT or aripiprazole SOT or olanzapine SOT | Not specify | NA |
| Jin et al. (39) | No | Amisulpride, aripiprazole, haloperidol, olanzapine, quetiapine, risperidone, placebo, clozapine | NA | NA |
LAI, long-acting-injection; ODT, orally disintegrating antipsychotic tablets; SOT, standard oral tablets; PP3M, paliperidone administered every 3 months; PP1M, paliperidone administered every month; NA, not applicable.
#
If patients show no response to the therapies or relapse during the current treatment, they will change to the next-line treatment.
*
A single drug different from the previous treatment line was chosen as the current treatment line.
**
Clinical and economic inputs were determined by a weighted average with equal proportions of data for the drugs.
***
Clinical and economic inputs were determined by market share of the drugs.