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Changes in reactive oxygen species levels with SIRT6 haploinsufficiency. Note that superoxide levels are significantly increased in SIRT6+/– mice compared to SIRT6+/+ mice (* denotes p < 0.05). Inhibition with apocynin, an inhibitor of NAD(P)H oxidase, significantly decreased reduced superoxide levels in both groups of mice (SIRT6+/+ n = 5 and SIRT6+/– n = 6).
