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. 2021 Oct 20;12:753501. doi: 10.3389/fphys.2021.753501

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Copyright © 2021 Greiten, Zhang, Roos, Hagler, Jahns and Miller.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in endothelial function in SIRT6 haploinsufficient mice. (A) Responses to acetylcholine in SIRT6^+/+ and SIRT6^+/– mice. Note that responses to acetylcholine are significantly impaired in SIRT6^+/– mice, and that vasodilation to acetylcholine is normalized by incubation of vessels with the NAD(P)H oxidase inhibitor apocynin. (B) Responses to sodium nitroprusside in SIRT6^+/+ and SIRT6^+/– mice. While there is a rightward shift of the curve in SIRT6^+/– mice, this trend did not reach statistical significance. (C) Constrictor responses to the thromboxane receptor agonist U46619 in SIRT6^+/+ and SIRT6^+/– mice. Note that peak force generation is significantly reduced in SIRT6^+/– mice. (D) Responses to serotonin in SIRT6^+/+ and SIRT6^+/– mice. Note that contractile responses to serotonin are significantly impaired in SIRT6^+/– mice compared to controls (SIRT6^+/+ n = 9 and SIRT6^+/– n = 12). * denotes p < 0.05.