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. 2021 Oct 20;12:670338. doi: 10.3389/fimmu.2021.670338

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Copyright © 2021 Liu, Gokhale, Jung, Zhu, Luo, Saha, Guo, Zhang, Kyin, Zong, White and Xie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRAF3 regulated the number and morphology of mitochondria in resting B cells. Splenic B cells were purified from gender-matched, young adult (8-12-week-old) naïve LMC or B-Traf3 ^-/- mice. Purified cells were analyzed directly (Day 0) or at day 1 after ex vivo culture. The number and morphology of mitochondria in cells were analyzed by electron microscopic (EM) examination. (A) Representative EM micrographs of resting B cells. Sick mitochondria are indicated with red arrows in the figure. (B) Graphical results of the number, width and length of mitochondria as well as the percentage of cells containing sick mitochondria (vacuole+) determined by EM examination. Graphs shown are the mean ± SD (n = 6/group; **p < 0.01; ***p < 0.001 by t test).