Table 3.

(A) Diameter stenoses (DS_CTCA and DS_ICA) and non-invasive FFR (FFR_AM and FFR_B) in study groups (FFR > 0.8 and FFR ≤ 0.8; (B) Comparison of diagnostic performance of different parameters for predicting myocardial ischemia at per-vessel level; (C) Comparison of diagnostic performance of different parameters for predicting myocardial ischemia at per-patient level.

Parameter	Overall (n = 169)		FFR > 0.80 (n = 96)		FFR ≤ 0.8 (n = 73)		p-value
(A)
DSCTCA ≥ 50%	129 (76%)		64 (67%)		65 (89%)		0.001
DSICA ≥5 0%	119 (70%)		49 (51%)		70 (96%)		<0.0001
DSCTCA ≥70%	54 (32%)		35 (36%)		19 (26%)		<0.0001
DSICA ≥70%	59 (35%)		44 (46%)		15 (21%)		<0.0001
FFRAM	0.80 ± 0.20		0.91 ± 0.09		0.67 ± 0.22		<0.0001
FFRB	0.80 ± 0.12		0.87 ± 0.08		0.71 ± 0.10		<0.0001
Threshold	Accuracy	Sens	Spec	LR+	LR-	PPV	NPV
(B)
DSCTCA ≥ 50%	0.57	0.89	0.33	1.33	0.33	0.50	0.80
DSICA ≥ 50%	0.69	0.96	0.49	1.88	0.09	0.59	0.94
DSCTCA ≥ 70%	0.66	0.47	0.81	2.49	0.65	0.65	0.67
DSICA ≥ 70%	0.76	0.63	0.86	4.57	0.43	0.78	0.75
FFRAM ≤ 0.8	0.81	0.75	0.86	5.48	0.29	0.81	0.82
FFRB ≤ 0.8	0.87	0.88	0.86	6.39	0.14	0.83	0.90
(C)
DSCTCA ≥ 50%	0.57	0.93	0.11	1.04	0.63	0.57	0.56
DSICA ≥ 50%	0.75	0.95	0.51	1.94	0.10	0.71	0.89
DSCTCA ≥ 70%	0.59	0.49	0.72	1.78	0.70	0.69	0.53
DSICA ≥ 70%	0.69	0.63	0.77	2.68	0.49	0.77	0.62
FFRAM ≤ 0.8	0.75	0.73	0.79	3.42	0.34	0.81	0.70
FFRB ≤ 0.8	0.82	0.86	0.77	3.69	0.18	0.82	0.82

Sen, sensitivity; Spec, specificity; LR+, positive likelihood ratio; LR-, negative likelihood ratio; PPV, positivity predictive value; NPV, negative predictive value.