TABLE 4.

Diagnosing efficacy of the combined biomarkers.

	Sensitivity	Specificity	Accuracy	AUC (95% CI)
Training cohort
Age + ApoE ε4 + olfactory	0.674	0.792	0.763	0.776 (0.718–0.834)
Age + ApoE ε4 + olfactory + rGSK-3β	0.730	0.836	0.810	0.846 (0.794–0.897)
Age + ApoE ε4 + olfactory + rGSK-3β + Aβ1-42/Aβ1-40	0.764	0.869	0.843	0.869 (0.822–0.916)
Validation cohort
Age + ApoE ε4 + olfactory	0.591	0.778	0.732	0.704 (0.657–0.750)
Age + ApoE ε4 + olfactory + rGSK-3β	0.716	0.849	0.777	0.848 (0.815–0.882)
Age + ApoE ε4 + olfactory + rGSK-3β + Aβ1-42/Aβ1-40	0.841	0.760	0.804	0.867 (0.835–0.899)

Bootstrap resampling times = 1,000.

AUC, area under curve; CI, confidence interval.