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. 2021 Oct 20;12:757186. doi: 10.3389/fpls.2021.757186

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Copyright © 2021 Forestier, Brown, Harvey, Larson and Graham.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Theoretical formation of GGPP/casbene and OH-GGPP/16-OH-casbene. (A) Condensation of dimethylallyl pyrophosphate (DMAPP) and isopentyl pyrophosphate (IPP) to form GGPP and cyclisation by casbene synthase to form casbene. (B) Condensation of HMBPP and IPP to form OH-GGPP and cyclisation by casbene synthase to form 16-OH-casbene.