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. 2021 Oct 20;12:757811. doi: 10.3389/fimmu.2021.757811

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Copyright © 2021 Sarkar, Spencer, Barnette, Pandey, Sutton, Basu, Burch, Cleveland, Rosenberg, Rangel-Moreno, Keefer, Hessell, Haigwood and Kobie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Frequencies of immune cell subsets in CD4 depleted and vaccinated rhesus macaques. (A) Immunization schedule: 27 adults rhesus macaques were assigned to this study and divided into two groups of nine for immunizations and the third group with nine macaques without immunization. All 18 rhesus macaques received VC10014 DNA plasmids and were then boosted i.m with co-immunization of VC10014 DNA plasmids and proteins in adjuplex. Nine rhesus macaques received CD4R1 during the priming phase. Flow cytometric analysis of longitudinal distribution of CD4+ (B) and CD8+ (C) T cells and total CD19+CD20+ B cells (D). Red=CD4 depleted (CD4d) group, turquoise =Immunized (Imm) group, black=Non-Immunized (NI) group. Thin lines represent individual animals, thick lines indicated group mean. Significance determined by the unpaired t-test comparing Imm and CD4d groups and are indicated as follows: p ≤ 0.001, *p ≤ 0.005, p ≤ 0.01, p ≤ 0.05.

Inline graphic — Frequencies of immune cell subsets in CD4 depleted and vaccinated rhesus macaques. (A) Immunization schedule: 27 adults rhesus macaques were assigned to this study and divided into two groups of nine for immunizations and the third group with nine macaques without immunization. All 18 rhesus macaques received VC10014 DNA plasmids and were then boosted i.m with co-immunization of VC10014 DNA plasmids and proteins in adjuplex. Nine rhesus macaques received CD4R1 during the priming phase. Flow cytometric analysis of longitudinal distribution of CD4+ (B) and CD8+ (C) T cells and total CD19+CD20+ B cells (D). Red=CD4 depleted (CD4d) group, turquoise =Immunized (Imm) group, black=Non-Immunized (NI) group. Thin lines represent individual animals, thick lines indicated group mean. Significance determined by the unpaired t-test comparing Imm and CD4d groups and are indicated as follows: p ≤ 0.001, *p ≤ 0.005, p ≤ 0.01, p ≤ 0.05.