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. 2021 Oct 20;12:757811. doi: 10.3389/fimmu.2021.757811

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Copyright © 2021 Sarkar, Spencer, Barnette, Pandey, Sutton, Basu, Burch, Cleveland, Rosenberg, Rangel-Moreno, Keefer, Hessell, Haigwood and Kobie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rhesus macaques develop longitudinal autologous and heterologous Env-specific antibodies. (A) F8-gp140 and SF162-gp140 specific plasma IgG was determined by ELISA. Symbol represented individual rhesus macaques. (B) Plasma samples from VC10014-vaccinated macaques were tested longitudinally for neutralization antibodies to F8, SF162, SHIV-BaL, and JRCSF (Tier 2) by TZM-bl assay. Longitudinal ELISA showing Pneumovax (C) and Tetanus (D) specific plasma IgG. Red=CD4 depleted (CD4d) group, turquoise =Immunized (Imm) group, black=Non-Immunized (NI) group. Significance is determined by two-tailed unpaired t-test (p ≤ 0.05).