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. 2021 Oct 20;12:757811. doi: 10.3389/fimmu.2021.757811

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Copyright © 2021 Sarkar, Spencer, Barnette, Pandey, Sutton, Basu, Burch, Cleveland, Rosenberg, Rangel-Moreno, Keefer, Hessell, Haigwood and Kobie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD4 depletion during priming phase reduces risk of infection. (A) Rhesus macaques were challenged intrarectally with increasing doses of SHIV-BaL virus. Survival curves showing CD4 depletion reduces risk of infection. (B) RT-PCR was used to quantitate viral SHIV-BaL RNA in plasma. (C) Assessment of tissue-related virus (copies per million cells). Red = CD4 depleted (CD4d) group, turquoise = Immunized (Imm) group, black = Non-Immunized (NI) group. Significant difference (p < 0.05) between groups as determined by two-tailed t-test and 2-way ANOVA, *p < 0.05, **p <0.005, ***p < 0.001, ****p < 0.0001.