TABLE 4.

Univariable and multivariable Cox regression analysis of the signature and survival of NFPA patients in the training, test group and entire group.

Variables		Univariable analysis				Multivariable analysis
		HR	95% CI of HR		P	HR	95% CI of HR		P
			Lower	Upper			Lower	Upper
Training set (n = 33)
Age	>52 vs.≤52	0.23	0.05	1.09	0.06	0.18	0.03	1.08	0.06
Sex	Male vs. Female	1.05	0.29	3.74	0.94	0.73	0.17	3.11	0.68
Tumor size classification	Macro vs. Giant	1.10	0.23	5.18	0.91	1.19	0.18	7.72	0.85
CS invasion	Yes vs. No	1.40	0.36	5.40	0.63	1.37	0.28	6.59	0.70
Signature	High risk vs. low risk	2.03	1.40	2.94	<0.001	2.06	1.36	3.12	<0.001
Test set (n = 33)
Age	>52 vs.≤52	0.35	0.09	1.36	0.13	0.62	0.15	2.67	0.52
Sex	Male vs. Female	0.53	0.14	2.03	0.35	0.78	0.17	3.72	0.76
Tumor size classification	Macro vs. Giant	0.31	0.09	1.08	0.07	0.15	0.02	0.88	0.04
CS invasion	Yes vs. No	2.05	0.53	7.92	0.30	0.43	0.06	3.29	0.42
Signature	High risk vs. low risk	5.49	1.16	14.92	0.03	6.96	1.21	40.16	0.03
Entire set (n = 66)
Age	>52 vs.≤52	0.29	0.10	0.79	0.02	0.33	0.12	0.93	0.04
Sex	Male vs. Female	0.75	0.31	1.81	0.52	0.89	0.36	2.18	0.80
Tumor size classification	Macro vs. Giant	1.21	0.82	1.78	0.33	0.59	0.21	1.67	0.32
CS invasion	Yes vs. No	1.72	0.66	4.48	0.26	1.23	0.42	3.54	0.71
Signature	High risk vs. low risk	1.49	1.24	1.80	<0.001	1.50	1.24	1.82	<0.001

CS, cavernous sinus; Giant, giant adenoma; Macro, macroadenoma.