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. 2021 Oct 12;24(11):103262. doi: 10.1016/j.isci.2021.103262

Figure 3.

Figure 3

Doxycycline induced adipocyte-specific NaKtide expression improves behavioral function, neuroinflammation and markers of cognitive function in the hippocampus of mice fed a WD

(A and B) Novel object recognition test analysis for (A) Time to 20 s criterion and (B) Total Exploration time.

(C–E) (C) Protein carbonylation assay in hippocampus homogenates. mRNA expression of (D) IL-6 and (E) TNFα.

(F) Plasma Aβ40 concentration. Immunoblot analysis for (A) BDNF (n = 6), (B) pTau (n = 4), (C) pERK (n = 6) and (D) PSD95 (n = 6). Results are expressed as means ± SEM. N = 4–14/group. Statistical analysis by one-way ANOVA, multiple comparison using Tukey's test, where ∗p < 0.05 vs. CTR, ∗∗p < 0.01 vs. CTR, #p < 0.05 vs. CTR + NaKtide, ##p < 0.01 vs. CTR + NaKtide, &p < 0.05 vs. WD, &&p < 0.01 vs. WD.