Figure 7.

Heatmap for protein-protein interaction of genes associated with the activation of Na,K-ATPase signaling

(A and B)WD gene expression shown as a heatmap in (A) visceral fat and (B) hippocampus. Protein interaction strength derived from the STRING database is shown as line thickness and inverse length using Cytoscape. Colors of WD vs Control (core) and WD + NaKtide vs WD (rim) range from log2FC of −2 to +2. Colors of the core and rim are reciprocal, indicating that NaKtide expression opposed or reversed the WD diet changes. N = 6/group.