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. 2021 Oct 20;11:742462. doi: 10.3389/fonc.2021.742462

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Copyright © 2021 Huang, Wang, Liu, Chu and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of TFDP3 in mid-to-late G1 phase. After pocket proteins (RB, p107 and p130) are phosphorylated by cyclins (CCNs) and cyclin-dependent kinases (CDKs) in early G1 phase, the E2F-TFDP complexes separate from pocket proteins in mid- to late-G1 phase. Meanwhile, repressive E2F4 and E2F5 are shuttled to the cytoplasm, and the activator protein E2F1-3 levels peak at this phase. When TFDP3 is present, the DNA-binding and transcriptional activities of E2F1-3 are inhibited. Consequently, the cell cycle-related protein is down produced and cell cycle can be arrested in G1 to some extent.