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. 2021 Oct 20;11:756326. doi: 10.3389/fonc.2021.756326

Figure 3.

Figure 3

Performance evaluation and clinical usefulness of the eHCC nomogram. (A) Nomogram was based on age, sex, alpha-fetoprotein (AFP), and the six-CpG-scorer. (B) Calibration curves of the eHCC nomogram in the training dataset. The x-axis represented the predicted probability of early HCC risk from nomogram. The y-axis represented the actual early HCC rate. The blue diagonal dotted line represented a perfect performance by an ideal nomogram. The red dotted line represented the performance of the eHCC nomogram; the green solid line represented bootstrap-corrected performance of eHCC nomogram. (C) Area under the receiver operating characteristic curve (AUROC) of eHCC nomogram in training dataset. Data were AUROC (95% CI). (D) Decision curve analysis (DCA) of the nomogram predicted early HCC in the training set. The x-axis indicated the threshold probability and the y-axis indicated the net benefit. The blue curve represented the eHCC nomogram. The red line indicated the assumption that all patients were early HCC. The horizontal green line indicated the assumption that there were early HCC. eHCC, early hepatocellular carcinoma.