Table 2.
All 18 variables included in the backwards feature selection analysis.
| Variable | Univariable | Multivariable | ||
|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Age (years), ≥43 vs. <43 | 5.07 (3.07–8.56) | 1.75e–07*** | 5.23 (3.24–8.63) | 2.56e-08*** |
| Sex (Female vs. Male) | 0.32 (0.17–0.56) | 0.0011** | 0.32 (0.19–0.53) | 0.000248*** |
| Alpha-fetoprotein (AFP) (ng/ml), log10 a | 1.50 (1.35–1.69) | 1.85e–09*** | 1.48 (1.34–1.64) | 3.05e-10*** |
| Six-CpG-Scorer | 2.37(1.83 –3.12) | 1.10e–07*** | 2.58 (2.01–3.36) | 1.08e-09*** |
| Total protein(g/L), ≥65 vs. <65 | 0.38 (0.19–0.71) | 0.01209* | 0.32 (0.20–0.51) | 0.56 |
| Total bilirubin(μmol/L), ≥21 vs. <21 | 0.32 (0.14–0.69) | 0.01588* | 0.45 (0.32–0.64) | 0.78 |
| AST (U/L), log10 | 0.77 (0.45–1.28) | 0.40551 | ||
| ALT (U/L), log10 | 0.51(0.43–1.06) | 0.15320 | ||
| Direct bilirubin (μmol/L), ≥7 vs. <7 | 0.55 (0.77–2.35) | 0.38832 | ||
| γ-GT (U/L), ≥45 vs. <45 | 1.15 (0.83–1.61) | 0.47649 | ||
| Albumin (g/L), ≥40 vs. <40 | 0.74 (0.41–1.36) | 0.42147 | ||
| Alkaline phosphatase (U/L), log10 | 0.77 (0.44–1.35) | 0.44623 | ||
| Hemoglobin (g/L), ≥115 vs. <115 | 1.68 (0.91–3.14) | 0.16827 | ||
| White blood cell count × 109/L, log10 | 0.84 (0.17–4.24) | 0.85430 | ||
| Monocyte count × 109/L, truncate_99 + log10 b | 2.29 (1.14–4.67) | 0.05410. | ||
| Platelet count × 109/L, ≥125 vs. <125 | 0.84(0.50–1.42) | 0.58796 | ||
| Lymphocyte count × 109/L, ≥1.1 vs. <1.1 | 0.82 (0.46–1.49) | 0.58026 | ||
| Neutrophil count× 109/L, log10 | 1.08 (0.37–2.86) | 0.89871 | ||
aNonlinear transformation.
bMonocyte count variable was truncated with 1st and 99th percentiles and then performed with nonlinear transformation.
OR, odds ratio; γ-GT, γ-glutamyltranspeptidase; ALT, alanine aminotransferase; AST, aspartate aminotransferase. Signif. codes: “***” 0.001, “**” 0.01, “*” 0.05.