Figure 1.

Possible mechanism through which RECK influences NAFLD/NASH development and pathogenesis. RECK’s inhibition of the gelatinases MMP2 and MMP9 may in turn reduce leukocyte invasion into the hepatic parenchyma and hepatic stellate cell activation. In addition, RECK inhibits the sheddases ADAM10 and ADAM17, which consequently may inhibit the release of proinflammatory cytokines from hepatic cells, as well as reduce activation of EGFR and Notch pathways, both of which contribute to inflammation and fibrosis of liver. © Copyright 2021 by The Curators of the University of Missouri, a public corporation.