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The positions of the detected variants in FOXC1 and PITX2. (A) is the diagram of FOXC1 protein and its variants. (B) is the diagram of PITX2 protein and its variants. The main function domains (forkhead domain in FOXC1 protein and homeodomain in PITX2 protein) are shown in black. The positions of the variants in FOXC1 and PITX2 are indicated by arrows. The novel variants are shown in red. Gross deletions spanning FOXC1 and splicing variants in PITX2 were not shown in Figure 1.
