Table 2.
Median age (years) of dementia diagnosis or dementia-free death by APOE ε4 status in the ARIC cohort (N = 13,782)a.
| Dementia | ||||||||
|---|---|---|---|---|---|---|---|---|
| White (n = 1,778) | Black (n = 834) | |||||||
| ≥1 APOE ε4 allele | No APOE ε4 alleles | ≥1 APOE ε4 allele | No APOE ε4 alleles | |||||
| Age | 95% CI | Age | 95% CI | Age | 95% CI | Age | 95% CI | |
| Overall | 83.3 | (82.8, 83.8) | 85.7 | (85.3, 86.1) | 81.7 | (81.0, 82.4) | 82.6 | (81.9, 83.4) |
| Males | 83.3 | (82.5, 84.2) | 84.7 | (84.1, 85.4) | 80.8 | (79.6, 82.1) | 81.3 | (79.9, 82.6) |
| Females | 83.4 | (82.8, 84.0) | 86.4 | (85.9, 86.9) | 82.2 | (81.4, 83.1) | 83.1 | (82.3, 83.9) |
| Dementia-free death | ||||||||
| White (n = 3,909) | Black (n = 1,571) | |||||||
| ≥1 APOE ε4 allele | No APOE ε4 alleles | ≥1 APOE ε4 allele | No APOE ε4 alleles | |||||
| Age | 95% CI | Age | 95% CI | Age | 95% CI | Age | 95% CI | |
| Overall | 77.9 | (77.2, 78.6) | 79.9 | (79.6, 80.4) | 74.1 | (73.3, 74.9) | 75.8 | (74.9, 76.5) |
| Males | 76.8 | (76.0, 77.7) | 79.4 | (78.9, 79.9) | 73.3 | (72.1, 74.5) | 74.8 | (73.7, 75.8) |
| Females | 79.2 | (78.0, 80.3) | 80.6 | (79.9, 81.3) | 74.8 | (73.7, 75.9) | 76.7 | (75.6, 77.8) |
CI, confidence interval; ARIC, Atherosclerosis Risk in Communities.
a
Results account for competing risk of death.
Note: Bold indicates difference by APOE status significant at p ≤ 0.05.