Table 3.
Proportion experiencing dementia diagnosis by APOE ε4 status in the ARIC cohort (N = 13,782)a.
| Dementia | ||||||||
|---|---|---|---|---|---|---|---|---|
| White (n = 1,778) | Black (n = 834) | |||||||
| ≥1 APOE ε4 alleleb | No APOE ε4 alleles | ≥1 APOE ε4 allelec | No APOE ε4 alleles | |||||
| % | 95% CI | % | 95% CI | 95% CI | % | 95% CI | ||
| Overall | 47.0 | (44.4, 49.6) | 33.9 | (32.0, 35.7) | 46.3 | (38.3, 54.4) | 36.6 | (33.5, 39.9) |
| Males | 40.6 | (37.0, 44.3) | 27.0 | (24.5, 29.1) | 37.6 | (27.1, 49.5) | 29.8 | (25.9, 34.2) |
| Females | 54.5 | (50.7, 58.2) | 41.2 | (38.4, 44.0) | 52.9 | (40.7, 62.5) | 40.3 | (36.6, 44.3) |
CI, confidence interval; ARIC, Atherosclerosis Risk in Communities.
a
Results account for competing risk of death.
b
Significantly different by APOE status at p ≤ 0.05 across both sex; no differences noted in overall proportion between sexes for White participants.
c
Significantly different by APOE status at p ≤ 0.05 across both sex; greater difference noted in proportion of dementia for females compared with males for Black participants.