Figure 3.

Bridge location and bridge areal densities across the tibial growth plate of mice. Location and areal densities of bridges across the growth plate projected on the medial (M) and lateral (L) tibial joint surface in non-operated (A), DMM (B), non-loaded (C) and loaded (D) tibiae of mice at 16 and 18 weeks of age, number of bridges in lateral and medial tibiae of non-operated compared to DMM and non-loaded compared to loaded tibiae of mice (E), Areal density (d) of bridges in medial compared to lateral tibiae, defined as the number of bridges per 256 mm x 256 mm window of non-operated and DMM or non-loaded and loaded knee joints (F). Bars represent mean ± SEM. Group sizes were n = 8 for non-operated and DMM-operated mice and n = 6 for non-loaded and loaded mice. * indicates differences between lateral and medial tibiae *p < 0.05 **p < 0.01 ***p < 0.001 ****p < 0.0001.