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. 2021 Oct 20;12:734988. doi: 10.3389/fendo.2021.734988

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Copyright © 2021 Samvelyan, Madi, Törnqvist, Javaheri and Staines

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MicroCT analysis of epiphyseal region of medial and lateral tibiae of mice. MicroCT analysis of the epiphyseal region of the lateral and medial tibiae in non-operated controls and DMM-operated knee joints subchondral bone volume fraction (SCB BV/TV) (A) and epiphyseal trabecular bone volume fraction (Tb. BV/TV) (B). MicroCT analysis of the epiphyseal region of the medial and lateral tibiae in non-loaded controls and loaded knee joints subchondral bone volume fraction (SCB BV/TV) (C) and epiphyseal trabecular bone volume fraction (Tb. BV/TV) (D). Representative colour coded images of lateral and medial subchondral bone plate thickness of non-operated and DMM-operated tibiae of mice (E). Representative colour coded images of lateral and medial subchondral bone plate thickness of non-loaded and loaded tibiae of mice (F). Representative colour coded images of epiphyseal trabecular bone thickness of non-operated and DMM-operated (G), or non-loaded and loaded tibiae of mice (H). Bars represent mean ± SEM. Group sizes were n = 8 for non-operated and DMM-operated mice and n = 6 for non-loaded and loaded mice. * indicates differences between lateral and medial tibiae *p < 0.05 **p < 0.01 ***p < 0.001.