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. 2021 Oct 20;11:746789. doi: 10.3389/fonc.2021.746789

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Copyright © 2021 Chen, Guo, Guo, Wu, Si, Xu, Kang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulators and functions involved in m6A modification. m6A writer, such as METTL3 and METTL14, binds to RNA to methylate adenine. Then, the m6A readers including YTHDC1/2, YTHDF1/2/3, IGF2BP1/2/3, and HNRNPA2B1 recognize the m6A site and participate in the process of RNA splicing, stability, nuclear transport, translation, degradation, or miRNA processing. In addition, m6A modifications can also be erased by FTO and ALKBH5, thereby affecting the fate of RNA. A, adenine.