Skip to main content
. 2021 Oct 20;11:706616. doi: 10.3389/fonc.2021.706616

Figure 3.

Figure 3

Exploration of immune landscape and immune response. (A) Single sample gene set enrichment analysis suggested a higher proportion of multiple immune cells such as activated B cells, CD8+ T cells, CD4+ T cells, and dendritic cells. ns for p>0.001, * for p<0.001, ** for p<0.0001, *** for p<0.00001. (B–D) Higher immune score, estimate score, and lower tumor purity are analyzed by ESTIMATE algorithm. (E, F) TIDE analysis estimated T cell dysfunction and exclusion and predicted response of immunotherapy. (G) Low-risk patients showed significantly higher PD-1 and CTLA-4. lncRNA, Long non-coding RNA; ssGSEA, Single Sample Gene Set Enrichment Analysis; TIDE, Tumor Immune Dysfunction and Exclusion. ns for p>0.05, * for p<0.05, ** for p<0.01, *** for p<0.001.