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. 2021 Oct 20;12:763647. doi: 10.3389/fimmu.2021.763647

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Copyright © 2021 Komai, Ito, Nomura, Shichino, Katoh, Yamada, Ko, Iizuka-Koga, Nakatsukasa and Yoshimura

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD8⁺T cells affect expression patterns of macrophage repairing factors. (A, B) Gene expression of CD45-positive cells 1 week after TAC in monocyte/macrophage clusters. (C) Expression of Igf1, Areg, and Osm 1 week after TAC (red: CD3ϵ^-/-KO TAC; blue: CD8⁺T cell depleted TAC; green: WT TAC) in monocyte/macrophage clusters. norm.exp: normalized expression [ln(x+1)]. (D) mRNA (Igf1, Areg, and Osm/Hprt1) of CD45⁺ (CD3ϵ^- CD19^- Ly6g^-) cells collected from 4-10 pooled hearts 1 week after TAC.