Table 1.
Cohort characteristics and associations with lacunar stroke and non-lobar intracerebral hemorrhage.
| Lacunar stroke (N = 82) | Non-lobar ICH (N = 54) | Mean differences (95% CI) | Univariable OR (95% CI) | p-Value | Multivariable OR (95% CI) | p-Value | |
|---|---|---|---|---|---|---|---|
| Demographics | |||||||
| Age at MRI, years, median [IQR] | 63 [57–72] | 66 [59–75] | 2.6 (–1.1; 6.6) | .198 | 0.95 (0.89; 1.01) | .092 | |
| Male sex, N (%) | 52 (63%) | 39 (73%) | 0.7 (0.3; 1.5) | .286 | 3.52 (1.26; 10.35) | .018 | |
| Vascular risk factors | |||||||
| Hypertension, N (%) | 66 (80%) | 32 (60%) | 2.8 (1.3; 6.2) | .012 | 6.72 (2.11; 24.76) | .002 | |
| Diabetes mellitus, N (%) | 15 (18%) | 8 (15%) | 1.3 (0.5; 3.4) | .597 | |||
| History of smoking, N (%) | 69 (84%) | 30 (57%) | 4.1 (1.8; 9.3) | <.001 | 3.38 (1.13; 10.71) | .032 | |
| Alcohol overuse, N (%) | 27 (36%) | 15 (29%) | 1.4 (0.6; 3.0) | .429 | |||
| BMI, kg/m2, mean (SD) | 27 ± 4 | 25 ± 5 | –1.2 (–2.8; 0.4) | .111 | |||
| MRI markers of SVD | |||||||
| WMH volume, % ICV, median [IQR] | 0.3 [0.1–0.8] | 0.4 [0.2–0.9] | 0.07 (–0.05; 0.2) | .227 | |||
| Presence of lacunes, N (%) | 36 (44%) | 9 (17%) | 3.7 (1.7–9.1) | .001 | 5.69 (1.66; 22.75) | .008 | |
| Presence of CMB, N (%) | 19 (23%) | 35 (67%) | 0.2 (0.1; 0.3) | <.001 | 0.08 (0.02; 0.26) | <.001 | |
| ICV, mL, mean (SD) | 1484 (146) | 1476 (166) | –7.7 (–67; 52) | .969 |
ICH: intracerebral hemorrhage; CI: confidence interval; OR: odds ratio; IQR: interquartile range; SD: standard deviation; BMI: body mass index; WMH: white matter hyperintensities; CMB: cerebral microbleeds; ICV: intracranial volume. Values represent median [IQR], N (%), or mean (SD). Information on history of smoking was missing in 1 (1%), alcohol overuse in 8 (6%), WMH volumes in 9 (7%), presence of lacunes in 2 (1%), CMB presence in 3 (2%), and ICV in 5 (4%) patients. Multivariable odd ratios and corresponding 95% confidence intervals represent results from the logistic regression analysis for lacunar stroke versus non-lobar intracerebral hemorrhage (ICH) adjusted for age, sex, and vascular risk factors significant in univariate analysis.p-values (the significant ones are printed in bold).