Table 3.
Summary of findings for PICO 3. Monitored multicomponent interventions (lifestyle and pharmacological), compared to usual care for prevention of future cognitive decline or dementia?
| Certainty assessment | Number of patients | Effect | Quality of evidence | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Monitored multicomponent interventions | Usual care | Relative (95% CI) | Absolute (95% CI) | ||
| Cognitive decline (statistically significant decrease of function in at least 2 of 5 cognitive domains) | ||||||||||||
| 1 | Randomised trials | Not serious | Not serious | Serious | Very serious | None | 8/76 (10.5%) | 10/83 (12.0%) | OR 0.86 (0.32 to 2.30) | 15 fewer per 1.000 (from 78 fewer to 119 more) | ⊕○○○ Very low | Important |
CI: confidence interval; OR: odds ratio. PICO: Population, Intervention, Comparator and Outcome.