Table 6.

Summary of findings for PICO 9. Assessment of the diagnostic accuracy of iterations of the Addenbrooke’s Cognitive Examination (ACE) for contemporaneous diagnosis of post-stroke cognitive impairment or dementia.

Participants: Stroke survivors Settings: Variety (acute and post-acute) Intervention: Addenbrookes Cognitive Examination Reference standard: Clinical dementia diagnosis or multidomain impairment
Study	ACE version Diagnostic cut-off	Setting	N with PSCI	Accuracy	Risk of bias	GRADE
Morris et al. (2012)	ACE-R <75 ACE-R <82 ACE-R <88	Acute inpatient	51/61 (84%)	Sens 0.59 Spec 0.40 Sens 0.80 Spec 0.40 Sens 0.90 Spec 0.20	High	Very low a
Pendlebury et al. (2012)	ACE-R <88 ACE-R <90 ACE-R <92	Community (stroke and TIA)	39/91 (42%)	Sens 0.56 Spec 100 Sens 0.67 Spec 0.98 Sens 0.72 Spec 0.79	High
Goncalves et al. (2015)	ACE-R <72–73	Neurology department	18/18 (100%)	Sens 100 Spec 0.92	High
Lees et al. (2017)	ACE-III <82	Rehabilitation unit	27/51 (53%)	Sens 0.93 Spec 0.11	High

^aDowngraded due to risk of bias, inconsistency and imprecision.

ACE-R: Addenbrooke’s Cognitive Examination-Revised.