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. 2021 Oct 20;12:714833. doi: 10.3389/fimmu.2021.714833

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Copyright © 2021 Holliday, Earhart, Alnijoumi, Krvavac, Allen and Schrum

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dornase alfa treatment did not reduce BALF neutrophils. Control, day 0 and day 4 symbols are displayed as mean ± SEM of 11 subjects in the control group and 9 subjects in the treatment group. Each individual color-coded point with connecting line between day 0 and 4 represents a unique patient in the treatment group (N=9). Two patients only had samples from a single time point due to sample degradation. Only 11 subjects in the control group underwent BALF sampling during hospitalization and are represented by individual colored coded data points. No statistically significant difference was noted in (A) % Neutrophils, or (B) log transformed absolute neutrophil counts in the bronchoalveolar fluid between case control patients and patients prior to receiving dornase alfa.