TABLE 2.

Multivariate linear regression model with the frailty score as the dependent variable.

	Unadjusted model			Adjusted model*
Frailty score	β	95% CI	P	β	95% CI	P
CSVD burden	0.43	0.36–0.50	< 0.001	0.41	0.34–0.48	< 0.001
Total WMH score	0.39	0.32–0.45	< 0.001	0.33	0.26–0.40	< 0.001
Number of lacunes	0.33	0.26–0.39	< 0.001	0.31	0.24–0.38	< 0.001
Number of CMBs	0.08	0.01–0.16	0.024	0.06	−0.01−0.13	0.100
EPVS-BG score	0.22	0.14−0.29	< 0.001	0.17	0.10−0.25	< 0.001
PSQI score	0.48	0.41−0.54	< 0.001	0.43	0.36−0.50	< 0.001

CI, confidence interval; CSVD, cerebral small vessel disease; WMH, white matter hyperintensities; CMBs, cerebral microbleeds; EPVS, enlarged perivascular spaces; BG, basal ganglia; PSQI, Pittsburgh Sleep Quality Index.

*Adjusted for age, gender, education level, HAMD score, and vascular risk factors.