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. 2021 Oct 20;12:752762. doi: 10.3389/fneur.2021.752762

Figure 4.

Figure 4

Global and regional CBF–FCS coupling changes among subjects with different WMH loads. (A) Whole-brain CBF–FCS coupling alterations across voxels in samples of subjects with different WMH loads. (B) Between-group comparisons exhibited a decreasing trend in global CBF–FCS coupling from mild WMH group to severe WMH group (mild WMH group: r = 0.225 ± 0.108; moderate WMH group: r = 0.209 ± 0.132; severe WMH group: r = 0.156 ± 0.112), whereas no significant differences were identified in global CBF–FCS coupling among three WMH groups (F = 1.645, p = 0.199). (C,D) Altered regional CBF–FCS coupling among three WMH groups. Compared with mild WMH and moderate WMH group, severe WMH group showed significant aberrant CBF–FCS coupling in bilateral thalamus, ACC, and left parahippocampal gyrus. Data were shown as adjusted correlation coefficients between CBF and FCS controlling for age and sex. Error bars represent the SD. *p < 0.05. ACC, anterior cingulate cortex; PhG, parahippocampal gyrus; Tha, thalamus; WMH, white matter hyperintensities. L, left; R, right. Detailed information on brain regions is available at http://atlas.brainnetome.org/.