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. 2021 Oct 20;12:733035. doi: 10.3389/fneur.2021.733035

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Copyright © 2021 Öhlmann, Koenen, Labrenz, Engler, Theysohn, Langhorst and Elsenbruch.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regions in which gray matter volume was differentially correlated with gastrointestinal symptoms in patients with (A) ulcerative colitis and (B) irritable bowel syndrome compared to healthy controls, and (C) regions in which gray matter volume was differentially correlated with chronic stress in patients with irritable bowel syndrome compared to healthy controls (applying a significance level of p < 0.001, uncorrected for multiple comparisons). Axial slices are provided in Supplementary Figures 5–7. For details, see Tables 3, 4. AI, anterior insula; AG, angular gyrus; BF, basal forebrain; CAU, caudate nucleus; FO, frontal operculum; FP, frontal pole; IFG, inferior frontal gyrus; IOG, inferior occipital gyrus; MCC, middle cingulate gyrus; MFG, middle frontal gyrus; MTG, middle temporal gyrus; OP, occipital pole; PCC, posterior cingulate gyrus; PCG, precentral gyrus; PoCG, postcentral gyrus; SFG, superior frontal gyrus; SOG, superior occipital gyrus; THA, thalamus; TP, temporal pole.