Table 2.

Results of whole-brain ANCOVAs comparing gray matter volume in the two patient groups to healthy controls.

Brain region	H	k	TFCE	p FWE	x	y	z
UC < HCUC
Middle frontal gyrus	L	521	323.01	0.029	−42	20	45
Anterior insula	L	334	273.41	0.032	−23	23	−9
IBS < HCIBS
Postcentral gyrus	L	2,936	553.22	0.002	−29	−30	72
Precuneus	L	2,703	243.29	0.02	2	−75	53
Inferior temporal gyrus	R	755	255.01	0.018	51	−41	−32
Middle temporal gyrus	R	144	155.41	0.046	48	−41	−3
Lateral orbital gyrus	R	201	170.81	0.04	47	29	−18
Inferior occipital gyrus	R	805	226.23	0.023	56	−69	−12
	R	264	180.43	0.036	44	−89	5
IBS > HCIBS
Superior frontal gyrus	L	9,185	644.58	0.001	12	11	72
	R	631	208.35	0.028	24	45	47
	R	236	189.4	0.033	23	35	30
Middle frontal gyrus	L	109	176.01	0.038	−42	41	33
	L	110	170.45	0.04	−38	23	20
Inferior frontal gyrus (opercular part)	L	184	173.6	0.039	−59	14	21
Temporal pole	L	3,005	230	0.022	−24	3	−17
	R	383	196.58	0.031	33	26	−39
	R	254	178.35	0.037	35	−2	−30
Superior parietal lobule	R	163	205.23	0.028	9	−54	69
Middle cingulate gyrus	L	519	179.19	0.037	−11	24	26
Occipital pole	L	296	191.12	0.032	−14	−96	8

Results are FWE-corrected at p < 0.05 and the total intracranial volume, age, and sequence (where appropriate) were included as covariates of no interest. H, hemisphere; L, left; R, right; k, cluster size; TFCE, threshold-free cluster enhancement; x, y, z, MNI coordinates; UC, ulcerative colitis; HC_UC, matched healthy control group for UC group; IBS, irritable bowel syndrome; HC_IBS, matched healthy control group for IBS group.