Table 4.

Results of multiple regression correlating gray matter volume and chronic stress in patients with IBS and healthy controls.

Brain region	H	k	TFCE	p *	x	y	z
IBS < HCIBS
Angular gyrus	L	2,006	2,566.1	0.001	−44	−50	48
	R	5,402	2,119.6	0.004	44	−38	41
Temporal pole	L	7,230	1,836.4	0.01	−47	8	−14
	R	6,535	2,320.7	0.002	41	8	−27
Superior frontal gyrus	L	5,205	2,010.2	0.006	−20	51	8
Middle frontal gyrus	R	428	1,565.7	0.023	36	8	54
Inferior frontal gyrus (triangular part)	R	112	1,341.4	0.045	41	32	5
Postcentral gyrus	R	957	1,481.8	0.03	44	−5	32
Thalamus proper	R	6,057	1,696.7	0.016	6	−17	−2
Inferior occipital gyrus	R	430	1,362.4	0.042	44	−75	−8
Superior frontal gyrus	R	9,925	2,010.2	<0.001	−20	51	8
Inferior frontal gyrus (orbital part)	R	158	1,323.5	0.001	35	35	0
	L	120	1,280.1	<0.001	−42	26	2
Anterior orbital gyrus	L	314	1,048.9	0.001	−30	41	−6
Precentral gyrus	R	7,445	1,565.7	<0.001	36	8	54
Middle cingulate gyrus	L	642	1,192.4	0.001	−9	−11	39
Anterior insula	R	497	1,530.2	0.001	36	−11	9
Basal forebrain	L	191	1,427.6	<0.001	−9	5	−12
Caudate	L	113	1,310	0.001	−14	20	−3

^*P-values from FWE-corrected analysis are underlined; all other values indicate results from uncorrected analysis (interaction group x chronic stress). H, hemisphere; L, left; R, right; k, cluster size; TFCE, threshold-free cluster enhancement; x, y, z, MNI coordinates; IBS, irritable bowel syndrome; HC_IBS, matched healthy control group for IBS group.