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. 2021 Oct 20;12:751594. doi: 10.3389/fimmu.2021.751594

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Copyright © 2021 Liu, Wang, Yuan, Wei and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The landscape of Immune cells infiltration in the TME of OC. (A) Heatmap representing unsupervised clustering of infiltrating immune cells in two OC cohorts. (B) Kaplan–Meier curves showed OS of all patients between two ICI clusters. (C) The fraction of tumor-infiltrating immune cells and immune and stromal scores in the two ICI clusters. (D) Cellular fraction of the tumor-infiltrating immune cell types in ICI clusters. (E–H) Difference in PD-L1 (E), PD1 (F), PD-L2 (G), and CTLA4 (H) expression between ICI clusters. *p < 0.05; **p < 0.01; ***p < 0.001; ns, not significant.