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. 2021 Oct 20;12:751594. doi: 10.3389/fimmu.2021.751594

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Copyright © 2021 Liu, Wang, Yuan, Wei and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of ICI scores. (A) Alluvial diagram of ICI gene cluster distribution in groups regarding to different gene clusters, ICI scores, and survival status. (B) Immune-activity-related signatures and immune-checkpoint-relevant signatures in low and high ICI subgroups. (C) Interaction of immune cell infiltration and ICI score in two gene clusters. (D) Cellular fraction of the tumor-infiltrating immune cell types in high and low ICI, including Stromal Score and Immune Score. (E) Gene set enrichment plots showed the rich KEGG pathways in the high ICI subgroup. (F) Kaplan-Meier curves for high and low ICI groups in two OC cohort. *p < 0.05; **p < 0.01; ***p < 0.001; ns, not significant.