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. 2021 Oct 20;12:751594. doi: 10.3389/fimmu.2021.751594

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Copyright © 2021 Liu, Wang, Yuan, Wei and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The association between the ICI scores and somatic variants. (A) Tumor mutation burden (TMB) difference in the high and low ICI subgroups. (B) Scatterplots describing the positive correlation between ICI scores and TMB in the OC cohort. (C) Kaplan–Meier curves for high and low TMB groups of the OC cohort. (D) Kaplan–Meier curves for patients in the OC cohort stratified by both TMB and ICI scores. (E) The single nucleotide variants (SNVs) were constructed using high ICI on the left (blue) and (F) low ICI on the right (red). Individual patients are represented in each column. (G) Differentially mutated genes between low ICI and high ICI displayed as a forest plot.