Fig. 2.

Structural features of n3113 and n3113.1 in complex with RBD and spike ectodomain. a–e Crystal structure of RBD-n3113. a Overall structure of RBD-n3113. The RBD is shown in a blue cartoon. N3113 is presented in an orange cartoon with its three CDRs highlighted in red. b–e Detailed interactions between CDR3 (b), CDR2 (c), CDR1 (d), and FR (e) of n3113 and RBD. The residues involved in binding are shown in blue (n3113) and orange (RBD) sticks. Salt bridge and hydrogen bonds are shown as red and black dashed lines, respectively. f, g Cryo-EM structures of spike ectodomain with n3113 (f) and n3113.1 (g) Two perpendicular views of UDD-, UUD- and UUU-state complex are shown as surface. S2 subunit of S trimer is rendered in grey. The S1 (NTD and RBD) subdomains from each monomer are colored in blue, pink, and brown, respectively. N3113 and n3113.1 are colored in orange