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. 2021 Oct 20;12:692431. doi: 10.3389/fphar.2021.692431

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Copyright © 2021 He, Qu, Kwan Law, Qiu, Han, Ricardo de Seabra Rodrigues Dias, Liu, Zhang, Wu, Wu, Fai Mok, Cheng, He and Wai Wong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Atg7 knockout can reduce AGEs-induced apoptosis and calcification. Cells were treated with AGEs for 24 h. (A) Changes in protein expression in Atg7 knockout HASMCs. Western blot analysis of LC3 and Atg7. (B) Western blot analysis of calcification-related proteins (β-catenin, Runx2, OPN, and BMP2) in AGEs-treated HASMCs with or without Atg7 knockout. (C) Western blot analysis of apoptosis-related proteins (Caspase3, Caspase9, Bax, and Bak) in AGEs-treated HASMCs with or without Atg7 knockout. Each point represents the mean ± SD (n = 3/group). ^*** p < 0.001 and ^### p < 0.001 versus Atg7 and LC3 expression level in WT cells respectively, t-test analysis.