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. 2021 Oct 20;12:692431. doi: 10.3389/fphar.2021.692431

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Copyright © 2021 He, Qu, Kwan Law, Qiu, Han, Ricardo de Seabra Rodrigues Dias, Liu, Zhang, Wu, Wu, Fai Mok, Cheng, He and Wai Wong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Autophagy suppression rescues aortic calcification in vivo. (A) Representative images of HE and immunohistochemistry-stained aorta sections are shown. Areas of calcification lesions are shown with black and white tissues in detailed HE images at higher magnification. Immunohistochemistry images stained with RUNX2, and LC3-II are shown in lower panels. Tissues with brown color stand for the positive signal for corresponding antibodies. Scale bar = 50 μm (×10), scale bar = 10 μm (×20). (B) Western blot assay from the homogenized samples from the same aorta sections was detected. The expression of LC3-II was significantly higher in the DM group than WM co-treated group. Besides, RUNX2 and OPN expression in aortic tissue significantly decreased than in the DM group.