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. 2021 Oct 20;12:732874. doi: 10.3389/fphar.2021.732874

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Copyright © 2021 Li, Ke, Guo, Wu, Bian, Shan, Liu, Huo, Guo, Liu, Liu and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The mitochondrial membrane was examined using JC-1 probe (B) Apoptosis was evaluated using flow cytometry (C) R/G represents altered mitochondrial membrane potential (D) Apoptosis data was analyzed. ^### p < 0.001 compared to control group; ^** p < 0.01, ^*** p < 0.001 compared to H/R group. μM: μmol/L; R/G: Red/Green; H/R: hypoxia and reoxygenation, n = 3.