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. 2021 Oct 20;12:732874. doi: 10.3389/fphar.2021.732874

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Copyright © 2021 Li, Ke, Guo, Wu, Bian, Shan, Liu, Huo, Guo, Liu, Liu and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Protein expressions were evaluated with Western blotting (B) Keap1 quantification of Western blotting result was calculated (C) Nrf2 expression quantification of Western blotting result was inhibited (D) ATF6 expression data was analyzed (E) GRP78 expression data was analyzed. ^# p < 0.05, ^### p < 0.001 compared to control group; ^* p < 0.05, ^** p < 0.01, ^*** p < 0.001 compared to H/R group. μM: μmol/L; Keap1: Kelch Like ECH Associated Protein 1; Nrf2: Nuclear factor E2-related factor 2; ATF6: Activating transcription factor 6; GRP78: Glucose-regulated protein 78; H/R: Hypoxia and reoxygenation, n = 3.