Fig. 5. MAPK pathway inhibitors inhibit the production of (A–C) NO, (D–F) TNF-α, and (G–I) IL-6 production of RAW 264.7 macrophages induced by OTF hydrolysates (500 μg/mL).

OTH-Bro: (A), (D), (G); OTH-Pan: (B), (E), (H); OTH-Pap: (C), (F), (I). Values represent mean ± SD (*p < 0.05, **p < 0.01, ***p < 0.001 vs. control group). NO, nitric oxide; TNF, tumor necrosis factor; IL, interleukin; MAPK, mitogen-activated protein kinase; OTF, ovotransferrin; Bro, bromelain; Pan, pancreatin; Pap, papain.