Fig. 7.

Anticancer drugs and iron chelation reduce c‐MYC and G9a expression and increase FTH1 expression in BCa cells. (A) MCF‐7 and (B) MDA‐MB‐231 cells treated with the indicated doses of vitamin C, 5‐FU, SAHA, doxorubicin, and JQ1 for 48 h were assessed for the expression of FTH1, c‐MYC, and G9a by western blot. (C) The expression of FTH1, c‐MYC, and G9a was also examined in MCF‐7, MDA‐MB‐231, and SKBR3 cells treated with 50 or 100 µm of DFO for 48 h relative to untreated controls. β‐Actin was used as a loading control.