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. 2021 Oct 6;11(11):3101–3114. doi: 10.1002/2211-5463.13303

Fig. 8.

Fig. 8

Reduced c‐MYC and G9a expression associates with enhanced cell sensitivity to chemotherapy. Viability of MCF‐7 cells silenced for FTH1 24 h prior to treatment with increasing concentrations of (A) DFO, (B) 5‐FU, (C) vitamin C, (D) doxorubicin, or (E) JQ1. (A‐E) Error bars show the mean ± SD from four replicated experiments. Cell viability of MCF‐7 cells silenced for G9a 24 h prior to treatment with increasing concentrations of (F) SAHA or (G) 5‐FU or silenced for c‐MYC 24 h prior to treatment with increasing concentrations of (H) SAHA or (I) 5‐FU. MCF‐7 cells silenced for c‐MYC 24 h prior to treatment with increasing concentrations of SAHA or 5‐FU. Cell viability was assessed by CV staining at 72 h post‐treatment. (F, I) Error bars show the mean ± SD from four replicated experiments. One‐way ANOVA was performed to test for statistical significance among multiple groups; *P < 0.05, **P < 0.005, # not significant.