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. 2021 Oct 20;12:757194. doi: 10.3389/fphar.2021.757194

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Copyright © 2021 Wang, Li, Mao, Mo, Cao, Luo, Zhou, Liu, Zhang and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro evaluation of cell proliferation of exosomes. (A) Relative cell viability of HepG2 after 72 h incubation of HCC exosomes and SD-HCC exosomes; (B) the Annexin V/PI apoptosis assay was measured by FCM analysis of HepG2 cells after being treated with each group for 24 h. n = 3, ^*** p < 0.001. 1) HepG2, 2) HepG2 + HCC exosome, 3) HepG2 + SD-HCC exosome, 4) HepG2 + SD-HCC exosome + CTLA-4 inhibitor.