TABLE 1.
Demographic and tumor characteristics of colorectal cancer patients.
| DIR.LDH | |||||
|---|---|---|---|---|---|
| 0 | 1 | 2 | P | ||
| Age(years) | <65 | 353 (50.2) | 93 (13.2) | 15 (2.1) | 0.389 |
| ≥65 | 182 (25.9) | 51 (7.3) | 8 (5.5) | ||
| Sex | Male | 345 (49.1) | 84 (12.0) | 12 (1.7) | 0.389 |
| Female | 190 (27.1) | 60 (8.5) | 11 (1.6) | ||
| Family history of CRC | no | 469 (66.8) | 122 (17.4) | 20 (2.8) | 0.461 |
| yes | 66 (9.4) | 22 (3.1) | 3 (0.5) | ||
| BMI(kg/m2) | <25 | 404 (57.5) | 116 (16.5) | 17 (2.4) | 0.429 |
| ≥25 | 131 (18.7) | 28 (4.0) | 6 (0.9) | ||
| Smoking | No | 351 (50.0) | 107 (15.2) | 21 (3.0) | 0.007 |
| Yes | 184 (26.2) | 37 (5.3) | 2 (0.3) | ||
| Drink | No | 414 (58.9) | 27 (3.8) | 21 (3.0) | 0.122 |
| Yes | 121 (17.2) | 117 (16.7) | 2 (3.37) | ||
| Lymph node ratio | <0.07 | 353 (50.3) | 84 (12.0) | 13 (1.9) | 0.176 |
| ≥0.07 | 182 (26.0) | 60 (8.5) | 10 (1.3) | ||
| Location | Left colon | 87 (12.4) | 37 (5.2) | 5 (0.7) | <0.001 |
| Right colon | 339 (48.3) | 32 (4.6) | 8 (1.1) | ||
| Rectal | 109 (15.5) | 39 (5.6) | 10 (6.6) | ||
| postoperation radiotherapy | No | 504 (71.8) | 134 (19.1) | 22 (3.1) | 0.845 |
| Yes | 31 (4.4) | 10 (1.4) | 1 (0.2) | ||
| TNM stage | 1 | 63 (9.0) | 11 (1.6) | 2 (0.3) | <0.001 |
| 2 | 194 (27.6) | 39 (5.6) | 4 (0.6) | ||
| 3 | 211 (30.1) | 44 (6.3) | 1 (0.1) | ||
| 4 | 67 (9.5) | 50 (7.1) | 16 (2.2) | ||
| Cea (ng/ml) | <3.5 | 308 (43.9) | 54 (7.7) | 5 (0.7) | <0.001 |
| ≥3.5 | 227 (32.3) | 90 (12.8) | 18 (2.6) | ||
| Ca199 (ng/ml) | <35.5 | 413 (58.8) | 94(13.4) | 10 (1.4) | <0.001 |
| ≥35.5 | 122 (17.4) | 50 (7.1) | 13 (1.9) | ||
| Circumferential margin | No | 527 (75.1) | 140 (20.0) | 21 (3.0) | 0.027 |
| Yes | 8 (1.1) | 4 (0.6) | 2 (0.2) | ||
| Vascular cancer embolus | No | 383 (54.6) | 103 (14.7) | 14 (2.0) | 0.537 |
| Yes | 152 (21.6) | 41 (5.8) | 9 (1.3) | ||
| Nerve infiltration | No | 412 (58.7) | 121 (17.2) | 17 (2.4) | 0.273 |
| Yes | 123 (17.5) | 23 (3.3) | 6 (0.9) | ||
| Differentiation | Poor | 68 (9.7) | 19 (2.7) | 9 (1.3) | 0.032 |
| Moderate | 408 (58.1) | 110 (15.7) | 13 (1.9) | ||
| Well | 59 (8.4) | 15 (2.1) | 1 (0.1) | ||
| neoadjuvant | No | 166 (23.4) | 39 (5.6) | 7 (0.9) | 0.658 |
| Yes | 369 (52.6) | 105 (15.0) | 16 (2.5) |
Abbreviation: CEA, carcinoembryonic antigen; CA199, carbohydrate antigen 19-9; DIR, direct bilirubin/indirect bilirubin; LDH, lactate dehydrogenase; DIR.LDH, the combination of DIR and LDH.